The Alpha1 protein circulates in the bloodstream and works to protect the lungs from inflammation due to infection or inhaled irritants, such as tobacco smoke.
People with Alpha1 deficiency have low or absent levels of the protective Alpha1 protein.
Alpha1 deficiency is an inherited disorder in which a genetic mutation impacts the body’s ability to produce sufficient levels of the Alpha1 protein.
A person who inherits two deficient Alpha1 genes—one from each parent—has Alpha1 deficiency.
Without enough functional Alpha1, lung damage can develop, usually in people between 20 and 50 years of age.
A severe Alpha1 deficiency may lead to emphysema—a lung condition that causes shortness of breath—with symptoms that can worsen over time.
Everyone has two copies of the Alpha1 gene. If both parents have one deficient Alpha1 gene and one normal Alpha1 gene, there’s a 25% chance their child could have two deficient genes and Alpha1 deficiency, a 50% chance their child could carry one deficient gene, and a 25% chance their child would inherit two normal Alpha1 genes.
Alpha1 deficiency is the most common known genetic cause of emphysema.
Your healthcare professional can help if you have questions about family testing, living with Alpha1 deficiency, or augmentation therapy.
Augmentation therapy with ARALAST NP is typically given once a week to help replace the low or absent levels of the protein.
An infusion of ARALAST NP may take approximately 15 minutes, depending on body weight and infusion rate.*
*Infusion time is estimated, based on a 165-lb adult patient receiving the recommended dose at the maximum infusion rate, based on the product labeling.
Actual infusion time will vary from person to person.
From the moment you enroll in OnePath, your dedicated Patient Support Manager will work with you one-on-one to help you access your prescribed Takeda medication.
The following are covered up to the program maximum and may be paid directly to the provider:
At a minimum, to be eligible for the program, a patient must:
For more information, please contact OnePath at 1-866-888-0660, Monday through Friday, 8:30 AM to 8:00 PM ET.
Other eligibility requirements apply. For more information, please contact a OnePath Patient Support Manager at 1-866-888-0660.
†IMPORTANT NOTICE: The OnePath Copay Assistance Program (the Program) is not valid for prescriptions eligible to be reimbursed, in whole or in part, by Medicaid, Medicare (including Medicare Part D), Tricare, Medigap, VA, DoD, or other federal or state programs (including any medical or state prescription drug assistance programs). No claim for reimbursement of the out-of-pocket expense amount covered by the Program shall be submitted to any third party payer, whether public or private. The Program cannot be combined with any other rebate/coupon, free trial, or similar offer. Copayment assistance under the Program is not transferable. The Program only applies in the United States, including Puerto Rico and other U.S. territories, and does not apply where prohibited by law, taxed, or restricted. This does not constitute health insurance. Void where use is prohibited by your insurance provider. If your insurance situation changes, you must notify the Program immediately at 1-866-888-0660. Coverage of certain administration charges will not apply for patients residing in states where it is prohibited by law. Takeda reserves the right to rescind, revoke, or amend the Program at any time without notice.
‡Subject to program terms, limits, and conditions